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S2 Bioengenharia e Qualidade de Vida |
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Title:
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MATHEMATICAL MODELING OF BLOOD GLUCOSE METABOLISM AND THE ARTIFICIAL PANCREAS DEVELOPMENT
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Summary :
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ABSTRACT. MATHEMATICAL MODELLING CONSTITUTES AN IMPORTANT STEP IN THE IMPLEMENTATION OF A CLODED-LOOP BLOOD (PLASMA) GLUCOSE CONTROL SYSTEM (ARTIFICIAL PANCREAS). THE ENDOCRINE-METABOLIC SYSTEM RELATED TO THE LEVEL OF BLOOD GLUCOSE IS HIGHLY COMPLEX, INVOLVING SEVERAL INTERMEDIATE PROCESSES OF PRODUCTION, STORAGE AND USE OF SUBSTRATA (AS THE GLUCOSE, THE GLYCOGEN OR THE GLUCOSE-6-PHOSPHATE) AND HORMONES (AS THE INSULIN, THE GLUCAGON AND THE ADRENALINE). IN THIS CONTEXT, MATHEMATICAL MODELS CAN BE USED FOR NON ACCESSIBLE PARAMETERS ESTIMATION , AS WELL AS FOR SIMULATION AND ANALYSIS OF CONTROL ALGORITHMS PERFORMANCE. IN THIS WORK, THE ROLE OF MATHEMATICAL MODELLING AS A FUNDAMENTAL PART ON THE DEVELOPMENT OF AN ARTIFICIAL PANCREAS IS DISCUSSED. BASED ON THE CURRENT LITERATURE, A PHYSIOLOGIC MODEL (WITH 9 COMPARTMENTS) RELATIVE TO THE WHOLE BODY IS PRESENTED AND SIMULATED. THE RESULTING MODEL INTENDS TO DESCRIBE THE INTERACTIONS BETWEEN SUBSTRATA AND HORMONES IN THE PORTAL CIRCULATION AS WELL AS IN THE SISTEMIC CIRCULATION AND INCLUDES SOME IMPORTANT EXTENSIONS FROM THE CLINICAL POINT OF VIEW, AS THE EXPLICIT DEPENDANCE ON THE PATIENT S DIET, A SUBMODEL FOR THE GLUCOSE ABSORPTION FOR THE GASTROINTESTINAL TRACT AND THE CONSIDERATION OF PHYSICAL ACTIVITY AND EXHIBITION TO STRESS. FINALLY, ITS POTENTIAL APPLICATIONS ARE PRESENTED.
KEY WORDS: GLICEMIC CONTROL, ARTIFICIAL PANCREAS, MATHEMATICAL MODELLING.
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Author :
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Fleury, Agenor de Toledo
Lopes, Jos?Augusto 0
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Paper View :
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